Magus Tech (Technological Wizard)

"In the current wizarding world similar to the Middle Ages, it is very difficult to use penicillin to treat infected pneumonia." Li Cha had this idea in his mind, "and penicillin can only kill some bacteria, and has little effect on fungi. Get rid of that thought."

So, without penicillin, what to use?

The answer to this question is - sulfa.

Penicillin is the first antibacterial drug discovered in the world, and it is also the most widely used antibacterial drug on the modern earth, but it is not the first antibacterial drug to be widely used.

1930s - Penicillin was discovered, but in the process of trying to increase production, sulfa drugs have been used as effective drugs for the treatment of hemolytic streptococcal infections and used in clinical treatment.

In the next ten years, sulfa drugs developed rapidly. By the 1940s, hundreds of different sulfa drugs had been produced.

In the early part of World War II (1939-1945), sulfonamides were a common drug used by the military to treat infections. There are sulfa powder and sulfa pills in the first aid kit of the US military. The sulfa powder can be sprinkled on the wound to inhibit infection, and the sulfa pill can be taken orally to deal with gangrene and pneumonia.

Um, pneumonia.

Sulfonamides saved lives during the war, including big names like Franklin Delano Roosevelt, Jr., the son of US President Roosevelt, and Winston Churchill, the British prime minister, who was suffering from pneumonia.

Therefore, no matter how you look at it, under the premise that penicillin is unreliable, sulfonamide is the real life-saving straw.

But it is too early to say that all problems have been solved.

If you think about it carefully, sulfonamide cannot be produced casually, otherwise such an important thing would not be used as a clinical treatment until before World War II.

The reason for this is that sulfanilamide is a chemically synthesized drug, a derivative of p-aminobenzenesulfonamide. In other words, in order to manufacture it, a certain level of chemical industry is required.

This level would be on Earth in the 1900s, as this is when the first sulfanilamide derivatives were chemically synthesized.

And the original synthesis was not used as a therapeutic drug. At the beginning, people didn't realize the magical effect of this thing, but simply regarded it as...a dye.

Yes, dye.

synthetic products,

It has bright colors, hardly fades, is superior to all previous dyes, and is widely used in the dyeing industry.

It is worth mentioning that the color of this dye is red.

Well, red.

So how did this red dye finally become a drug after decades?

This mainly relies on the very brainy German scientist-Hard Domak.

In the autumn of 1932, Dormark worked for Farben, hoping to find a drug that could specifically kill pathogenic bacteria. After some consideration, he decided to start with a bacterial stain.

Domark's logic is this: the dye can change the color of the bacteria, which means that some special changes have taken place in the internal structure of the bacteria. As long as a dye is found that can only change the color of specific bacteria and destroy the internal structure of the bacteria without affecting the rest of the cells, isn't it an excellent specific antibacterial drug?

After continuous efforts, Domac discovered the red azo dye-Pertrones from thousands of candidate azo dyes.

After research, Pronoccus has a strong effect on the treatment of hemolytic streptococcal infection.

Relying on a hundred waves and more breaths, Domark rescued his daughter who was suffering from streptococcal septicemia due to infection at one stroke, and won the Nobel Prize in Medicine in 1939.

The mechanism of Prontosil is a prodrug, that is, it has no activity in vitro, but after entering the organism, it can decompose the derivative of p-aminobenzenesulfonamide—sulfonamide. Sulfa and the p-aminobenzoic acid needed for the growth of bacteria are very similar in chemical structure, which will allow the bacteria to absorb it misleadingly but have no effect, and eventually die.

To be honest, the biggest effect of Prontosil is actually to inhibit bacteria, not to kill them, which is different from penicillin.

In addition, Bailang Duoxi has a disadvantage that cannot be ignored, that is, after use, it will change the color of the body, because it is a dye after all.

But anyway, he is indeed a life-saving drug.

So how to get it?

The way to obtain it is generally to put p-aminobenzenesulfonamide in an alkaline solution and use potassium ferricyanide or potassium permanganate to oxidatively couple amino groups to synthesize it. It can also be synthesized by reductive coupling of p-nitrobenzenesulfonamide with zinc powder.

All in all, all in all, troublesome.

It's not impossible, but because there is no chemical industry level corresponding to the modern earth at the beginning of the 20th century, many raw materials need extra preparation. And the raw material of making raw material needs the raw material preparation that does not exist in addition.

So there is a need for raw materials for raw materials.

What is frustrating is that the raw materials of raw materials often do not exist in nature, and still need to be produced - under the premise of lacking a complete industrial system, they often have to face it. If you want to synthesize something across the ages, except for opportunistic , In addition to finding another way, it is necessary to establish a small half of the industrial system that is lacking.

However, Li Cha didn't have to experience this inner breakdown.

Because a hundred waves are full of rest, he owns it.

Yes, he has a hundred waves and more breaths!

Red dye, with high medicinal value, isn't it what Alex sent in the box before!

At the beginning, he realized the value of the dye and accepted it, but now it's time to use it.

Thinking of this, Li Cha supported his tired and weak body, and walked towards the wooden frame next to him.

...

Outside the laboratory, in the yard.

Pandora stood, frowning, not understanding why Richard drove her out, did she do something wrong?

It shouldn't be, she was very obedient during this time, and even offered to help clean the test tube. Maybe in the process of washing the test tubes, I broke a few...dozens...well, I broke a few hundred, but she couldn't blame it all.

Whoever made the test tube slippery, it is very difficult to grasp, especially if it is contaminated with water, it will fall to the ground if you are not careful. She grabbed it with such great strength in order not to break it, and it was completely understandable that she accidentally crushed it.

Or is it……

Pandora remembered the pale face of Li Cha she saw before.

"Da da da……"

Pandora quickly ran to the window, grabbed the window sill, stood on tiptoe vigorously, and looked into the laboratory.

Through the cloudy glass, Pandora could see that Li Cha was frowning tightly, drank the strange liquid, and then forced himself to do some things, looking very strenuous.

She should help.

Pandora thought so, and suddenly saw Li Cha in the laboratory approaching the window sill, covering his mouth and nose, knocked on the irregular glass on the window, and said to her: "Be obedient, stay in the yard Just don't think about coming in. Don't worry about me, I'm fine."

"Er—" Pandora said, let go of the window sill she was holding, and walked back to the middle of the yard, pouting her lips and taking a sullen walk. A long stone of more than 20 centimeters stood in front of it without eyes. Pandora kicked it away, and the stone rolled out.

Suddenly Pandora turned her head, looked at the kicked stone, her eyes flickered, and then turned her head to look at the laboratory, as if thinking of something.

Quickly running to the side of the kicked stone, Pandora picked it up, then found another stone and held it in her hand, trying to start beating.

"Bang bang bang..."

Pandora beat it very carefully, much more carefully than when washing the test tubes, the 20 cm long stones dropped debris little by little.

Pandora stopped beating for a while, tilted her head to think for a long time, and then continued beating.

In the intermittent voice, the long stone in Pandora's hand slowly took shape - a human shape.

In the laboratory, after Li Cha took Bailang Duoxi, he was carrying out the rest of the auxiliary treatment.

The sky is dark and the night continues...