Rebirth of the God-level Xueba

Pharmaceutical companies in Jinyuan World are very willful. If Yang Rui is a Chinese-American, let alone discussing business with Pfizer, he will thank the Lord Longen if he can be recruited by Pfizer.

If it doesn't work, it's a group of lawyers who rushed forward to make you doubt life.

Today, Yang Rui is the head of the ion channel laboratory, the owner of the Huarui laboratory, the first generation of the Yang Rui genetic engineering laboratory, the inventor of PCR, the pioneer of the human gene era, and the king of G protein coupled receptors. A breakthrough in ion channels, a Nobel Prize winner, a true king of genetic engineering, a master of cattle embryos, a maker of Chinese medical standards, a pioneer of the 863 plan, a savior of millions of arrhythmia patients, Chinese and foreign media The male god, the father of cloned sheep, the terminator of thalassemia, the expander of coenzyme Q10, the lightning rod of the Chinese scientific community, the supreme monarch of sixty-four experimental dogs...

As a pure Chinese and a Chinese scientist, backed by the big tree of China, he can question life together with foreign and state-owned enterprises, and he can also formulate policies to make pharmaceutical companies that want to develop in China look up at the stars and lament the injustice of the world. .

Being a big boss in China, a closed and huge market economy country, has such advantages. Unlike countries such as Japan and South Korea, if you want to implement a drug closure policy, you have to consider the implementation of security regulations.

If you want to say, how powerful is the strength of pharmaceutical companies, especially Jinyuan? Needless to say, it will affect the policies of other countries. In order to make money together with insurance companies, they can change the medical insurance policy and let people die.

However, China has never been a country that plays cards according to common sense.

Even without Yang Rui, Pfizer will encounter many problems in China. For example, the name "Viagra" was preemptively registered by domestic companies. As a result, the lawsuits for several years were inconclusive. Until the end of the patent period, Pfizer could only use Viagra to name it.

The problems Pfizer encountered did not end there. After the expiration of Viagra's patent, domestic Jin Ge raised the banner of competition. In addition to advertising, their most ruthless move was to enter Viagra into the prescription drug industry.

For a long period of time, Chinese people who want to buy Viagra need to write a prescription to buy, while Chinese people who want to buy Jin Ge can go to any small pharmacy and get what they want as long as they bring money.

Is this competition justified? At least at the policy level, this is the result of competition.

Whether a drug can be marketed, whether it will be included in the list of prescription drugs, whether there are any special requirements, whether it can be produced in the country, whether it must be produced in the country, or whether to do further testing and clinical trials, is ultimately the decision of various committees. The guys decided.

Facing a market with 1.2 billion people and an average annual growth rate of more than 10%, Pfizer is easily unwilling to offend the bigwigs.

Even, in order to make up for the relationship, Pfizer also spent money to invite a China pass to go to China specifically to discuss with Yang Rui.

"Frankie? Why did you come on behalf of Pfizer and didn't do it at Zelecom?" When Yang Rui saw Pfizer's representative, he was very dazed for a few seconds.

He hasn't seen this British big fat in a while.

Frankie smiled like a toasted doughnut, and said: "I opened a special consulting company to provide services about China for pharmaceutical companies, and my income has doubled several times."

"I'm the boss by myself? Great!" Yang Rui gave his old acquaintance Comrade Frank a thumbs up.

He liked this chubby Englishman. Compared with the common arrogant and prejudiced foreigners nowadays, Frankie was more sensible and communicated better.

Frankie can eat this bowl of rice because everyone likes him.

Seeing that Yang Rui agreed with his choice, Frankie was very happy, so he used the Chinese he had just learned, with his tongue pointed, and said, "It's all due to my brothers!"

Yang Rui laughed haha, clicked on Frankie, and said: "With your hard work in learning Chinese, I want to invite you to dinner. Well, go to my laboratory. I will let Old Man Yu take the charge."

"Chef Yu's craftsmanship is three-star." Frankie said, greedy. He is talking about Michelin three-star, the highest state.

"Yeah, you have eaten chef Yu's meal, that's good, I won't need to introduce it. Would you like to order?" Yang Rui showed out Chinese hospitality. He has no such mood for strange foreigners.

"Let's invite Chef Yu to choose." Frankie paused after speaking, and said, "If possible, stew lion heads. I want two."

"Well, there are two big fist stewed lion heads. Chef Yu will choose the rest. There is one..." Yang Rui looked at Frankie's wider figure and said, "There is a seven or eight dishes, it should be almost the same. , A bigger portion."

Frankie listened to the translator's whisper and nodded again and again: "A big portion, a big portion is good."

Neither of them had the intention of discussing business, but Pfizer's manager, Connell, was extremely happy, thinking that the six-figure expenses were finally in vain.

Chef Yu is getting older, and he has less time to cook in person, but more time to think. The taste of the dishes he makes has improved.

However, his apprentices do most of the dishes.

It is said that he is an apprentice, and now he is also a master chef. It is also a small celebrity in the culinary world.

For example, Frankie’s favorite braised lion’s head, the traditional method is to use a flat knife to slice the pork ribs into pomegranate seeds. The best ratio is fat seven and thin three. However, the second apprentice of Chef Yu, Have begun to consider health factors.

The lion head he made is not as fatty as Master’s. While using the fat-to-lean ratio of five to five, he uses ice water to skim the oil, which not only maintains the tender, smooth and chewy texture, but also increases the proportion of lean meat, making the lion stewed. The head is healthier and more suitable for people who don’t lack meat.

Of course, there is no way to say something like eating too much because it is delicious.

As for authenticity or not, Yang Rui didn't care anymore.

Modern people eat famous dishes, and the attitude of pursuing authenticity is the least authentic. Authenticity can only be said to be in line with the taste of a generation, but it is in line with the taste of a literati poker. The worst, it is also in line with the preferences of people in a region, and there is still a long way to go from delicious.

From this point of view, eating authentic food is equivalent to a tourist queuing and a photo taken at the entrance of the scenic spot. It is eaten for the circle of friends.

"Professor Yang, how did you think of buying sildenafil?" Fran Wizard leaned back on the chair, touched his belly with his hand, and smiled and asked about serious things.

"I am optimistic about the prospects of nitric oxide drugs." Yang Rui did not hide his approval, took a sip of wine, and spoke slowly.

Sildenafil is an active drug that has been tested for animal safety. No matter how cheap it is, it costs tens of millions of dollars. If it is not recognized and promising, there is no reason to buy it.

Nitric oxide drugs are also the most popular types of drugs in the past two years. The most famous of the so-called nitric oxide drugs is nitroglycerin, which is the Nobel explosive ingredient and also has a miraculous effect on angina pectoris, but for a hundred years, people did not know why.

It was not until the end of the 1980s, that is, in the past two or three years, that the biological community slowly understood that it turned out that organic nitrates such as nitroglycerin can increase the concentration of second messengers in human tissues, and their production The mode of action is to metabolize nitric oxide.

This is a brand new mode of signal conduction, and it is a deep understanding of human beings about themselves.

The term nitric oxide has become so popular that it will even win the Nobel Prize in a few years.

Pfizer also carried out research on sildenafil. They screened a large number of molecules and finally selected this small molecule compound named UK-92,480.

It can be seen from its naming label that it takes a lot of trouble to sift out a molecule.

Although Yang Rui believes that there must be other molecules that can exert similar or stronger effects, but if you give him tens of millions of dollars, or even hundreds of millions of dollars, it really may not be able to be screened out.

Pfizer is reluctant to put it on the shelf for this reason.

Nitric oxide drugs have just become lively, and now they are sold. It is not easy to screen out a usable one that is as safe as this.

However, China is also a big market that has just become lively, and Pfizer is unwilling to find a big obstacle for itself as soon as the door opens.

Frankie took Pfizer's money and naturally wanted to help Pfizer. He also drank a sip of white wine, grinning with a spicy grin, and then happily said: "Why do you like Cedinafil, or it must be it? Didn't it make Pfizer ask the price?"

On the surface, he was helping Yang Rui to speak, but he was actually raising the price.

Pfizer was still unwilling to sell, and Yang Rui was forced to talk about it at this time. The first choice was to make a sky-high price.

Yang Rui was not surprised, holding a glass of wine, and said: "I chose sildenafil because it has the best safety among nitric oxide drugs. Huarui’s first drug is safe and effective. Sex is something you need to pay attention to."

"Hey, is this your business direction?" Frankie was suddenly distorted by Yang Rui.

Yang Rui nodded and said, "Fine. Okay, let's talk about Pfizer's offer."

"You are so anxious, don't you let people charge high prices? Why bother." Frankie used the same method again.

Yang Rui leaned on the chair, put his hands to the side, and said with a big boss expression: "Let's try it out."

"This..." Frankie was shocked by Yang Rui.

His task is very simple, contact Yang Rui, relax the relationship, and give an offer. If he angers Yang Rui and destroys the Chinese market, Pfizer is unhappy, and he will be blinded.

"Connell, come on." Frankie quickly found a scapegoat.

Pfizer’s manager didn’t care. He didn’t know Yang Rui and didn’t establish any relationship. After hesitating for a few seconds, he said: "If only sildenafil is sold in the Chinese market..."

"There is no such thing. What you are holding is a compound, and it is not a compliant drug. Did I develop a new drug and sell it only in China? Am I crazy?" Yang Rui interrupted Connelly immediately. .

It takes hundreds of millions of dollars to develop a new drug if it goes well. There is no reason to sell it in one place.

If the disease of the aliens can be cured, the pharmaceutical company dare to invest money to restart the Apollo project.

Connelle asked for a price, and smiled: "You can give us the market outside of China..."

"Agent sales is a future thing, now we will talk about the trading of compounds." When Yang Rui really wants to sell small blue pills, he still needs a foreign pharmaceutical company to act as an agency company, but that is a future thing. I haven't seen it. It doesn't make sense to talk about these until the effect of the drug.

Conil just said casually, he couldn't help but glance at Frankie at this time, and then said: "We have spent hundreds of millions of dollars to develop sildenafil..."

"If you are entertaining me, there is no need." Yang Rui stood up all at once.

"Professor Yang Rui, how about our cooperative development? If you are interested in sildenafil, we are willing to use an open solution. Cooperating with you, the cooperation solution can be very open." Connell hinted desperately.

For Pfizer, the allure of Nobel Prize winners is also very great.

Especially Yang Rui, he has a successful precedent for developing new drugs, and he is also a cutting-edge biologist who made G protein-coupled receptors. His qualifications are better than those of Tlett, the current person in charge of sildenafil. It can be said that as long as Yang Rui is willing to cooperate and the terms are not too harsh, Pfizer is very interested.

Even if he has nothing to do, when the time comes, sildenafil's new drug will be developed by a Nobel Prize winner, and it may be able to sell for hundreds of millions of dollars.

This is also the biggest reason why Frankie can get a six-figure salary.

He immediately said, "Professor Yang, this is a rare opportunity. You can put forward whatever conditions you have. Sildenafil has only done animal experiments, and it is still far from being marketed. You may also sell at that time. How about starting cooperation now?"

Deferiprone is a long-term recycling project~www.NovelMTL.com~ Yang Rui didn't bother to take the time to do it, so he sold it in a milestone way.

Even if Viagra wants to cooperate, it is after discovering its true effects.

"Find someone who can make a decision and let him make a price." Yang Rui was not affected by Frankie's words at all, and then said: "I can charge a higher price, otherwise, I will buy other types of nitric oxide compounds. If I develop it first, the value of sildenafil will be greatly reduced."

The greatest value of a new drug is that it uses a completely new mechanism to treat diseases.

In other words, patients who have not tolerated certain drugs in the past may be more suitable to take new drugs. New patients represent higher sales.

Naturally, if there are similar drugs on the market first, the drugs later on the market will inevitably be affected. Especially in accordance with the rules of the US FDA, drugs that are later on the market must be compared with the drugs that are on the market earlier.

If the efficacy of the drug is equal or inferior, the later-developed drug cannot even be listed. For a company, the blow to the stock price alone is enough.

This is a business decision worth hundreds of millions of dollars, which Connell cannot make.

He immediately bowed his head and said, "I will notify the company headquarters immediately."

After he finished speaking, he said in a small way: "Mr. Yang Rui, I hope our negotiations will not interfere with Pfizer's business in China..."

"Of course it will interfere." Yang Rui is not a little white rabbit, and calmly said: "A company that can't make correct business judgments is not doing business well. You can tell the Pfizer leadership in the original words."

"Professor Yang, I toast you a glass." Frankie was not convinced.

The more domineering Yang Rui is, the more he likes it. It is impossible for Pfizer to give up the market of one-sixth of the world's population. Yang Rui's barrier is what they must pass.

Frankie only thinks that his consulting company has a lot to do.