Rebirth of the God-level Xueba

"What's going on?" The people in the laboratory gathered naturally. ︾乐︾文︾小︾说|

Huang Mao turned to an electronic screen on the experimental platform and said: "I saw a significant potassium electron flow before, and I was sure that it was detected again. Look at the record, the average single conductance exceeds 250 picosi per meter. The single channel conductance is ten times greater than that of the ordinary potassium ion channel."

Pissi per meter is the unit of conductivity and one of the single-channel inspection signs. Ten times the conductivity is definitely abnormal. Everyone immediately gathered around to look at the recording paper.

Yang Rui looked around for a while and realized what had happened.

This seems to be a feature encoded by family genes.

Yang Rui quickly searched in his mind and found 4 members of the family, and then a little bit dumbfounded.

Huang Mao duly found the first member of the family channel.

This is two things to the shaker channel that Yang Rui envisioned.

The shaker channel is the first potassium ion channel identified in history, and it is also the first potassium ion channel identified through gene cloning. There are quite a few papers describing it, and it is relatively simple to do.

Yang Rui originally considered that he was the first to make a shaker channel, and it was easy to add something to form a standard paper.

Even if you copy a paragraph from the Shaker channel paper that will actually be published in 1987, you may be able to publish it in Nature.

However, scientific research is sometimes so unprepared.

It is not about what results you want to achieve.

Historically, most scientific research results, especially breakthrough scientific research results, were unexpected surprises. In many cases, they were even the result of mistakes.

It is true that the shaker gene was the first potassium channel to be discovered, but the person who discovered it did not know what he would find.

Just like Huang Mao now, although he is mutagenizing the gene of fruit flies, he doesn't know which gene he will mutagenize, or in other words, after the mutagenesis, he is not sure whether he can find it.

After two or three months of experimentation, Huang Mao has not observed the uncontrolled shaker of the fruit fly's calves like the scientists back then. On the contrary, Huang Mao has found a phenomenon that is not easy to observe. : Increase in conductance!

Of course, the so-called not easy to observe is also relative.

The shaker gene is also called the leg shaker gene. If this gene has a problem, the voltage of the potassium ion channel of the fruit fly will also have a problem. As a result, when the fruit fly is stunned by ether, the calf will keep shaking.

For so many people in the Huarui laboratory, they did not know hundreds or thousands of mutagenesis, or did not mutagenize the leg-shaking gene, or mutagenized it. At that time, there were no stunned fruit flies, so no such mutagenesis was observed. Phenomenon-this is also normal. If the phenomenon of gene mutation is so easy to observe, the biological world would not have played with fruit flies for decades. In the 21st century, they are still playing with fruit flies...

In terms of ethnicity, fruit flies have suffered more than eight lifetimes of mould than mice.

In comparison, the shaker gene is easy to observe externally, while the increase in conductance observed by Huang Mao is the easiest phenomenon to be observed on the instrument.

Because what you are doing is potassium ion channels, it is also intended to observe the conductivity of potassium ions. The channel is even more special. Its gene performance is a 10-fold increase in conductivity.

In this way, even if the accuracy of the instrument is not high, an order of magnitude change is still easy to notice.

"Show me the experimental record." Yang Rui was still a little excited. To determine potassium channels by means of mutated genes, the focus is to confirm the appearance of mutated genes.

If it is described in words, this is a very simple process: induce mutations in gene a, and find that the organism has changed b, so it is natural to determine that the function of gene a is to keep b unchanged.

For example, if the shaker gene is mutated, the legs of the fruit flies tremble, so it is determined that the function of the shaker gene is to keep the legs of the fruit flies from shaking.

Doing this step is actually a very good paper, but it may not be able to be listed in "Nature".

If you want to confirm that you are going to "Nature", you have to repeat the induction process continuously, and then determine why your legs and legs do not shake. In the end, it turns out that it is a voltage problem. Add a smooth article. This is basically a good paper in "Nature". Up. Of course, if you want to be in "Science", you don't care about the content, and the writing must be a bit literary...

As a scholar in the natural sciences, the retreating hairline of "Science" can circle the earth for seven and a half times!

Huang Mao was also in a state of excitement, and quickly found a few boxes from the top cabinet, then turned out the experimental records and handed them to Yang Rui.

His experimental records are very detailed, which is also Yang Rui's request, or experience.

Twenty years later, all foreign laboratories have adopted video experiment recording, the purpose is to record the experiment in detail.

People who have just finished the experiment will remember the experiment process very clearly, but after a few weeks, months, or years, the memory fades very badly.

In the end, a research institute with a good memory may remember the main steps or minor steps of the experiment, but which instrument is used for the experiment? Which chemical reagent is used in the experiment? 100 out of 100 people can't remember it.

These details do not matter one or two. The whole experiment will be too much. If it is a long-term experiment that lasts for several years, when it is re-verified or re-compared, is it possible to do the experiment again?

Just do it again, the chemical reagents provided by different companies are also different, and the result is a deviation, and who is it.

Falling into the potassium channel experiment, Yang Rui first had to make sure that in the case of abnormal electrical conductivity, the experimental conditions did not change drastically.

Fortunately, the conductance of the channel changes very drastically, and the change of 10 times is basically difficult to influence from the outside world, which makes the audit work relatively easy.

When Yang Rui reviewed it from beginning to end, Tu Xian and others had already congratulated Huang Mao.

On the contrary, Huang Mao himself was a little bit concerned about gains and losses. While looking at Yang Rui's unchanged expression with fear, he smiled and said, "Looking at your red eyes, the second author is also jealous?"

"Who is jealous of you, our old Tu has also achieved results recently, isn't it?" Wang Xiaoyun has the advantage of being a woman, and she can speak more casually.

Huang Mao smiled deliberately, changing to a smug expression, and said: "The potassium channel essay, the first one can take a big advantage, the second one is not necessarily the case."

"As far as your current research progress is concerned, it's not certain whether you can do the first one, isn't it?" Wang Xiaoyun poked her husband.

"I only need to do the experiment. How about the paper, Yang Rui is in charge." Tu Xian ignored his wife's aggressiveness.

Wang Xiaoyun punched him helplessly and said, "I am not motivated."

"I haven't been motivated to do experiments every day." Wei Zhenxue cried out strangely, and said, "Your two parents-in-law are working like this, and everyone else's kids should go to elementary school."

Wang Xiaoyun blushed immediately and she dared not speak. Both of them are busy in the laboratory and naturally have no time to give birth. This is slightly different from the ordinary marriage in the 1980s.

Tu Xian smiled instead and said, "Old Wei, can a single person have a baby?"

Wei Zhenxue's momentum stagnated ~www.NovelMTL.com~ for a long time, and came up with a wonderful counterattack method, and said: "Do you believe that I will make IVF by myself?"

At the level of Huarui's laboratory, there are really hardware conditions for IVF, and Wei Zhenxue also has the corresponding operating foundation.

However, Wei Zhenxue only has this way of talking.

Normal people are at least looking for a big breasted beauty or something.

Tu Xian was stunned by Wei Zhenxue's unexpected answer. At this time, Wang Xiaoyun asked coldly: "Have you used the test tube of mung bean soup?"

"Puff..." The experimental dog Sun Ruyue, who had been afraid to speak, couldn't help it anymore and chuckled.

Tu Xian and Huang Mao also kept coughing.

Wei Zhenxue looked as usual, and said, "I told you that the test tube is filled with mung bean porridge, and the one that is separated is mung bean soup."

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