Rebirth of the God-level Xueba

Yang Rui quickly set up a drug research group in Huarui's laboratory, and selected Wei Zhenxue to cooperate, plus two scientific research Wangs, even if the grass platform team for iron ketones was set up. Great God Ring (.. no pop-up ads)

Everyone is not optimistic about Yang Rui, including the interior of Huarui Lab.

Had it not been for the great prestige he had accumulated over the past year or so, the colleagues in Huarui's laboratory would have opposed Yang Rui's decision like Xu Zhengping.

During this time period, opposition is a normal response.

Pharmaceutical research itself is a very professional field. In original drug companies, those researchers who spend half of their energy on a drug are basically god-like in the field of subdivision and specialization. After Reagan's bill, universities and research institutions at all levels, some experts and scholars from academia to industry, greatly enriched this field, and also raised the threshold of pharmaceutical research infinitely high.

Not to mention the grass team, just spend tens of millions to form a team, and they dare not call the dream team in the field of drug research.

Scholars in academia are born to look down on researchers in industry, but it is true that the number of Nobel Prize winners in industry is really not much less than that in academia, especially between the 1980s and the 1990s, when they won awards. It’s popular for scholars to change jobs because the big pharmaceutical companies pay too much. The quotations of millions and tens of millions of dollars make it difficult for tenured professors with an annual salary of 70,000 dollars to support themselves. In addition, those forty-year-olds Professors who received a near-lifetime achievement award at the age of fifty are indeed lack of pursuit in the academic world. Many people have plunged into the ocean of industry and even business. Rich family warm marriage love

Super pharmaceutical companies such as Zellycan have never feared the challenges of small pharmaceutical companies. Their greatest magic weapon is acquisition. They will use a price of 30-50 million or even 100 million U.S. dollars to convert all promising small-scale pharmaceutical companies. Pharmaceutical companies are in the pocket-even if they can't, they will buy out the products of small pharmaceutical companies directly.

For example, Sister’s technology would be resold at a price of US$300 million without Yang Rui’s intervention, and several Nobel Prize winners in Sister’s company are also using this money. After improving his life, he went to work in other companies...

All in all, modern pharmaceutical companies are the companies that have the highest technical requirements and are also those that need technology the most. In contrast, the industry outside the pharmaceutical companies has been basically separated from the academic circles. For example, the academic experts who study machinery are basically trapped in physics. The world can’t extricate itself. Metallurgists are making materials, making materials all day long tossing microscopic crystals, and crystal elements are checking sanitation. Computer professors don’t know what they should do for a long time...

Only the research and development of pharmaceutical companies can use Nobel Prize-level scholars from theory to production. In other words, the world's top technology can be directly used in end products. Super auction house [.. super good-looking j

This process is naturally extremely complicated, and sometimes it is even carried out by luck. For example, desferiprone is an iron chelator, but no pharmaceutical company’s research team has ever thought of saying, “I’m going to find an iron chelator. "A mixture", or "inventing an iron chelator", he can only obediently wait for an iron chelator to be discovered, and then consider how to make it into medicine.

Only after the discovery of deferiprone can there be a chance to make deferiprone drugs.

This is also the first step in the pharmaceutical industry, the choice of drug targets.

After the target, there are more troublesome researches on drug synthesis and pharmacokinetics.

In order to pass the inspections of the national drug administrations, all steps must be carried out without fail, and strictly recorded. If you get past the thunder pool, you will face a situation where clinical trials are not approved—unless the researcher uses himself to do the experiment, otherwise, one The development of this new drug is now over. Bailian Ascension Record

In fact, Yang Rui didn't know the specific process, but he was not in a hurry.

He was not originally a person with a background in medicinal chemistry or pharmaceutical synthesis. He didn’t understand the process and what’s the matter. His current focus is to synthesize deferiprone first, and then look at the effect. If the effect is good, he can find someone in time. .

Of course, with Yang Rui's confidence, he asked Li Zhangzhen to find someone at the same time.

No one else understands Yang Rui's self-confidence, but Wei Zhenxue doesn't care at all. He only needs to have experiments to do. The more tall the experiment, the more Comrade Wei Zhenxue likes it.

When the two of them went back to West Castle Middle School, no matter what others said or did, they just sullen their heads to do their own experiments.

"For the fourth time in the deferiprone experiment, 3-carboxy-2methyl-4pyrone and methylamine were directly reacted..." Yang Rui made a record of the experiment and started the experiment immediately.

Wei Zhenxue helped by the side and said in his mouth: "If you can't do it like this, if you can do it by direct reaction, people would not synthesize iron ketone long ago."

"It's because the predecessors haven't made too many attempts. When they first discovered deferiprone, they only did research on iron chelation, and did not carefully study the synthesis of deferiprone. Lei Wu" Yang Rui shrugged and said. : "The method used by the predecessors is too low."

"It's too low. I don't think he knows how to synthesize the compound." Wei Zhenxue laughed and said, "The yield is less than 1%, and it's not pure enough. I don't know how many people will be poisoned to make a medicine. Very poisonous, the name is. How?"

Yang Rui didn't say a word, still looking at the test bench.

Wei Zhenxue boasted: "It's not that I said, I am a chemistry major. I was a coal chemistry person and published many papers. I don't know what the level is. The method he used is really not good. The one you use is even worse. It’s better to listen to me. Let’s start with the protection of the carboxyl group, find a way to methylate, and then deprotect the group. It is estimated that you can get deferiprone..."

"It's also a way." Yang Rui was noncommittal.

"My method is more reliable." Others don't talk to Yang Rui like this now. Only Wei Zhenxue has not changed his original intention for many years.

Yang Rui smiled and said: "It is indeed more reliable, but it is also more troublesome. Let's first consider whether simple methods can be made or not, and then consider complex methods."

"You said the opposite."

"I can't control that much, let's do this first." Yang Rui replied casually.

Yang Rui’s current method is a chemical synthesis method invented only in 1994, which is the cheapest synthesis method.

Needless to say, it was a substitute usage in the 1960s and basically cannot be used in industrial production. As for the method proposed by Wei Zhenxue, if a few more changes, there will be a chance to synthesize iron ketone, but Yang Rui is not going to adopt it.

Because he only needs one way to produce deferiprone. As a researcher who is not familiar with chemical synthesis, it is normal for Zhan Dayun to obtain a simple and convenient chemical synthesis method. If Zhan Dayun obtains more It's impossible.

Therefore, Yang Rui did it all at once and simply used methylamine to directly react.

However, in accordance with normal chemical thinking, direct reactions such as one-time generation have never been easy. In the words of scholars, it is unreliable.

Generally speaking, people are more inclined to find a simple way to produce first, and then gradually improve it. Just like coenzyme q10, Yang Rui has modified it for three times, and it has not been in place yet, and Zelecom is also very satisfied.

Unfortunately, desferiprone is not as profitable as coenzyme q10. Yang Rui is more inclined to establish a pharmaceutical company through this work. Therefore, his focus is on clinical trials and the application process, rather than pharmaceuticals. process.

Therefore, after doing a few wrong experiments, Yang Rui couldn't help himself. He was even more lazy to upgrade step by step. He took out the technology that a certain scholar had only made 10 years later, and let the gas and liquid in his own experiment. Wandering over the table.

Wei Zhenxue shook his head repeatedly, and said, "Yang Rui, it's not that I said, you are indeed a genius biologist, the strongest I have ever seen, and Peking University probably can't find any better than you. But biology is different from chemistry. You are Biologist, re-biological genius, what you are good at is also biology, but I am a chemist. Synthetic chemistry should listen to me, right?"

"Let's do it first..." Yang Rui perfunctory Wei Zhenxue.

"If you don't listen to me, why are you looking for me?" Wei Zhenxue said with an aura: "If you don't listen to me, I will go back."

With that said, Wei Zhenxue was about to leave.

Yang Rui was stunned. UU read www.uukanshu.com and said, "I asked you to be an assistant, but I didn't ask you to be an uncle."

"Is that so?" Wei Zhenxue paused when he left.

"of course."

"You don't want me to help you synthesize desferipone?"

"You are an assistant to help."

"So... I thought you let me take charge of the work." Wei Zhenxue turned his ankle and returned to the test bench, saying, "Then I will be an assistant."

"It was originally." Yang Rui couldn't laugh or cry. He hadn't experienced Wei Zhenxue's two for a while, and he was a little uncomfortable when he met him.

Wei Zhenxue never changed. He re-read Yang Rui’s experimental records, and the more he looked at him, the more he shook his head, and said, “Even if you don’t let me preside over the work, when I’m an assistant, I have to say, you It can’t be done like this!"

"Let’s wait and see." Yang Rui knew that he couldn’t do it a few times before, so he practiced his hands. He was familiar with the equipment and test methods in this area. This time, he used simple direct synthesis. confident.

Wei Zhenxue was also overwhelmed by his self-confidence, and vowed: "I'll wait and see, if you can use methylamine to synthesize iron ketone directly, I will twist your head off and give you a kick."

Yang Rui couldn't help laughing.

Huang Mao, Tu Xian, Li Wenqiang and others in the laboratory passed by curiously when they heard the bet.

Wei Zhenxue felt a chill on the back of his neck inexplicably.