Rebirth of the God-level Xueba

Grace's appearance aroused ripples in Huarui's laboratory.

There are a lot of foreigners in Yanjing City, and there are many people who pursue fashion, but it is not easy to see people with a beautiful figure and unique fashion taste like Grace.

At first glance, this looks like the costume of a female soldier on the battlefield. It is a bit rough, but when you look carefully, the large embroidery on the back of the jacket and the stitched leather on the leg surface are extremely different.

Through the window, Wei Zhenxue commented on the red-haired and blue-eyed girl without hesitation: "I was in the village. When I saw four colors at a time, I ran into a leopard."

"You grew up in the compound, when did you live in the village?" Huang Mao knew the basics of Wei Zhenxue, and one sentence pierced him.

Wei Zhenxue coughed and said, "My grandma lives in the village."

"Your grandma belongs to the Coal Bureau." Huang Mao sighed, worried about Wei Zhenxue's nonsense skills.

Wei Zhenxue coughed vigorously again and said, "What's wrong with the coal management bureau? If the coal management bureau is unhappy, there is a hometown."

"You can have a hometown, but your hometown is Datong, right? Does Datong have a leopard?"

Wei Zhenxue's lungs are about to come out, and said: "Just do it right with me, right? Why can't we have a leopard in the same zoo? We have a leopard head office in the same zoo, right..."

Think about it and think it doesn't match what he said before, Wei Zhenxue coughed again and continued: "Our leopard from the zoo in the same zoo ran out. I ran to our village and let me see it, okay!"

"It's all right..."

"What's the problem?"

"oo."

"Say it." Wei Zhenxue was angry all over.

Huang Mao stepped back a little bit and said, "The leopard has only three colors."

"What?"

"Yellow, black and white, didn't you go to the zoo to see it?" Huang Mao said with a smile.

Wei Zhenxue coughed vigorously and coughed vigorously: "I was in my grandma's hometown. I saw a leopard running out of the zoo. It was definitely in four colors. Maybe it was stuck with soot. Yes, it must be. coal ash."

"Soot is black..." Li Wenqiang asked in a low voice.

Wei Zhenxue wanted to cough up his lungs.

In the yard, Grace listened to the deafening coughing in the room and was a little worried, and asked, "Did any of you have the flu? Or a very serious pneumonia."

"No, they are playing games." Duan Bo, who went out to do research, lied without conscience.

"Learn the sound of pneumonia?" Grace said with rich imagination: "Is it a new project in your laboratory?"

"Of course not, they are just playing. Let's go to the laboratory..." Duan Bo led the two embarrassed people into the laboratory, and then introduced their recent work.

With her hand in her trouser pocket, Grace walked around the main laboratory handsomely and asked, "Who is Yang Rui? I heard that he is the main researcher of deferiprone, right?"

"Yes, Yang Rui hasn't come today." Duan Bo looked at his watch and said, "He only came here at noon in the last few days. Would you like to wait a little longer?"

"Of course, I'm here to see him." Grace said, looking for a place to sit down, and said: "Go ahead, I can see him by myself when Yang Rui comes. By the way, what does he look like?"

"What does it look like..." Duan Bo recalled the description that fits Yang Rui, and replied in written language: "The length is upright, very upright."

The translator faintly gave Grace a translator.

Grace didn't understand, "What's that?"

"I will know when I see you." Duan Bo replied.

Two hours later, Yang Rui appeared, and Grace really recognized it at a glance.

"Unexpectedly, there are men like this in China." Grace tilted her head and watched Yang Rui step by step with admiration.

At this time, Huang Mao was responsible for the company. He heard a strange expression: "There are no wonders in the world. There are hundreds of millions of people in China, and there are all kinds of men."

Grace shook her head and said, "Impossible."

Huang Mao was surprised: "Why?"

"I know all scholars above the level of biology, and there is no such thing as Yang Rui." Grace used the adjective she had just translated.

Duan Bo, who was introverted, couldn't speak instantly.

Grace stared at Yang Rui for a while, and then asked: "It took you three weeks to make 19 deferiprone derivatives?"

Yang Rui was also a little stunned by Grace's shape, and looked between her blue eyes and the high bridge of her nose, and said, "Are you the expert Van Lundin said?"

"Yes, this is our Professor Grace Bryan from Cambridge." Van Lundin suddenly sensed a deep sense of crisis. He stood directly between Yang Rui and Grace and said: "We can save a little bit of greeting time and use it to understand China. Rui's work on deferiprone."

"I think you mean my job." Yang Rui did not hesitate to take advantage of himself, and what he said was the truth. In the process of developing deferiprone, all except for the help of a few experimental dogs He does the work.

Van Lunding smiled happily: "Well, your job..."

"Can I see your experiment log? Unless it's too confidential."

"It's really confidential. You can see the part we selected." Yang Rui knows that some people want to learn about their work, especially the observations of professionals. His experimental records are complete and can withstand inspection, but as a kind of interview that has not yet been interviewed. Drugs, he has no reason to disclose all the information to the other party.

"The filtered part is fine too." Grace got the bound documents and quickly flipped through the past.

It is extremely difficult to synthesize a compound, but the molecular formula and synthesis process are horribly simple.

"I want to ask a question." Grace put the file aside and said, "Why did you choose to do desferiprone? With iron chelates, are hbed-type compounds and dft-type compounds more promising?"

"Perhaps, but I think it is more realistic to remove iron ketone." Yang Rui shrugged and replied.

Grace supported her chin with her hand, posed a pose, thought for a moment, and said: "If it were me, in order to make the product as soon as possible, I would choose. Its two phenolic hydroxyl groups and the 4-position n on the triazole ring constitute three. The chelating site, in terms of the affinity of iron ions, is similar to that of deferiprone, but its lipophilicity is stronger, which ensures the ability to enter cells after oral absorption. It is more realistic than deferiprone. ."

Her string of words instantly strengthened the research atmosphere in the laboratory. Several people looked at Yang Rui, wanting to hear his answer.

Yang Rui just opened his hand and said, "I am afraid that the specific performance of lipophilicity in the human body will be known after clinical trials. Before that, it is more difficult to synthesize, isn't it?"

Grace laughed and looked at Yang Rui with a fascinating gaze, and said: "You can synthesize 19 deferiprone compounds in 3 weeks. Isn't it easy to synthesize?"

Yang Rui was stunned. These words really hit his weakness.

Synthesized 19 kinds of deferiprone compounds in 3 weeks. Even if others say that Yang Rui is fast, Yang Rui does not matter. Anyway, I am fast because I am good, and you are slow because you are stupid. There is no need to say such subtext at all.

But Grace's question is very acute. Since Yang Rui is so good at synthesis, why doesn't he synthesize more difficult but more effective compounds?

Moreover, Grace has a very good vision. In the future generations, it will pass the review of the Food and Drug Administration and become a potent drug under the trade name of Delarox. It is stronger than deferiprone in terms of overall safety and efficacy. .

It is difficult for Yang Rui to explain this. He can never say that he is very worried about the risk of kidney failure caused by diferasirox. That is the potential risk that was discovered only two years after the listing of diferasirox. Yang Rui didn't even synthesize this kind of drug, how would he make a judgment?

From the perspective of future generations, we will re-examine desferiprone and deferriox. The latter is still superior to the former, but the risk of renal failure is a very strong negative item. Novartis did a clinical trial that year, or passed it through good luck. Or it is possible that the conspiracy theory is covered up, and these uncertainties are what Yang Rui tried to avoid.

It took several years and finally failed in the third phase of the clinical trial. This is the rhythm of the company going bankrupt.

Not to mention Huarui’s current third-party revenue of 10 million U.S. dollars a year, even medium-sized pharmaceutical companies with annual revenues of hundreds of millions of U.S. dollars often cannot afford the failure of Phase III clinical trials.

In the pharmaceutical field where investment is rising exponentially, most pharmaceutical companies will not even touch the second phase of the clinical trial. They are more willing to sell the drugs that have passed the first phase of the clinical trial at a good price, and then let the big companies pay a higher price. The risk of making greater profits.

After thinking for a long time, Yang Rui replied: “The drugs made are more complicated and the cost will be higher. I think that Chinese patients, and most of the dipine patients~www.NovelMTL.com~, need lower-priced drugs. "

"But the medicine made will be more effective." Grace looked directly into Yang Rui's eyes.

"If we can make this expensive drug after many complicated procedures...I still choose deferiprone. You may not have seen dipine patients in China. Many of them have not used deferipamine. Even if they need desferoxamine, the expensive price will stop them.” Yang Rui paused and said: “In China, in China at present, price is more important than curative effect. Cheap drugs can prolong patients than high-efficiency drugs. Longer life."

Yang Rui has read and understood enough information from the information collected by the hematologist Yong Xiaodong. At the same time, he also knows the past and present lives of the patients in the mainland. Therefore, his answer is true and true.

Grace fell into a long silence.

The laboratory also fell into a long silence.

Suddenly, Grace stretched out her hand, hooked Yang Rui's neck, and kissed it heavily.

The flaming red lips are intense and long.

"You are a real scholar, fighter, and a kind heart." Grace said softly after leaving Yang Rui.

But the surroundings are still silent, so silent that it is still.

The young, middle-aged and elderly in 1984 have never seen this.

Even the British Comrade Van Lundin had his eyes straight, like a locust tree struck by lightning.

...