Rebirth of the God-level Xueba

The number of candidate compounds is shrinking day by day

From the initial more than 30 kinds, to more than 20 kinds, and then to more than a dozen kinds, the rate of reduction slowed down until 13 kinds of compounds were left.

The compounds that were eliminated in the early stage were mainly caused by severe reactions in animal experiments. In fact, the new drug application rules of various countries are similar, but any severe reaction in animal experiments is not allowed to enter clinical trials, which means that a compound is eliminated.

This is a one-vote veto system, but from the perspective of a pharmaceutical company, it is the easiest part.

Because the compounds that have been rejected will not incur additional costs.

On the contrary, the remaining 13 compounds will continue to incur costs in the process of further animal experiments.

It's no more appropriate to describe this process as spending money like flowing water.

Batches of mice, rats and pigeons were orally stained with iron, and the candidate compounds were taken separately, and then various tests were performed.

The cost of all kinds of chemicals and equipment is more than 10,000 yuan per day.

Huang Mao and others did not personally participate in the study of the drug group, but they were frightened watching them from the side.

Seeing that it took them a week to reduce the number of candidate compounds from 13 to 12, Huang Mao couldn't help asking: "This kind of progress, isn't it going to be a year for animal experiments?"

Because Grace was here, Huang Mao spoke in English. The former immediately replied: "It is normal to do animal experiments for one year."

Huang Maomo calculated that the average research cost is more than 10,000 yuan per day. How much is the cost of animal experiments for one year? It's definitely more than 4 million yuan!

Although I have long known that developing new drugs costs money, the feeling of money flowing away from my eyes is even stronger.

Huang Mao couldn't help saying: "Our Huarui experiments have always exceeded the average speed, so you can't really do it for a year."

Grace tilted her head and thought for a moment. By the way, she straightened and stretched her waist. After revealing her beautiful figure, she said: "Internationally, there are an average of ten medicinal chemists and two to three biologists in laboratories developing new drugs Family participation...We have it now, let me calculate, I am a medicinal chemist, and two biologists, Yang Rui and Wang Xiaoyun, so you are right. Bigger."

Huang Mao's desire to complain can almost cover the entire laboratory: "Are you not in a hurry?"

After a long time, Huang Mao held out such a sentence.

"The laboratory can't afford medicinal chemists. What does it have to do with me."

"Wait five years, don't you waste five years too." Huang Mao didn't understand even more.

"No, five years from now, there will not necessarily be other pharmaceutical companies that will do desferiprone. Moreover, since we have started animal experiments, we must complete it. Otherwise, it will be a problem for other pharmaceutical companies. Responsible, irresponsible to thalassemia patients." Grace's thinking circuit is very strange.

Huang Mao didn't react for a long time, and asked, "Why?"

"Are you asking..."

"The irresponsible part."

"Grace's point is that if we stop half of our animal experiments, other pharmaceutical companies may think that our animal experiments are in such a bad situation that they completely abandon the deferiprone project." Yang Rui listened to their conversation. , Inserted a sentence, said: "We are currently in a good state. No pharmaceutical company will abandon the project at this stage. Therefore, unless we encounter other force majeure, the animal experiment will definitely be completed. If it is not completed, Other companies and even the fda will consider this situation. In the event of a lawsuit, lawyers will definitely look for the bottom line."

Huang Mao understood, and replaced it this time, and asked, "Is it good to be done?"

"Projects that have passed animal experiments can already be sold at a good price."

"How to sell?"

"There is a special market." Yang Rui is actually not very clear. Where did he have the opportunity to play games like mergers and acquisitions before.

Huang Mao widened his eyes and asked, "Is it expensive?"

"It won't be too cheap, just this expense." Yang Rui curled his lips.

Huang Mao also reacted instantly. For the experiments conducted by Huarui Lab in a cheaper way, it will cost 20 million yuan in five years. If a foreign company hires 10 medicinal chemists, two or three biologists, one The annual salary has to be paid out millions of dollars, let alone other costs.

"It's just too long." If it takes five years to earn tens of millions of yuan, Huang Mao doesn't think there is a high income. There are too many factories in China with annual profits of one million or ten million. Huarui Labs nowadays The expenses of US$1 million are also more than one million dollars, especially in the ongoing lawsuits. American lawyers have collected soaring fees, and 20 million yuan is not enough to fill the gap.

Thinking about it this way, when it was time for lunch to eat, Huang Mao deliberately sat next to Yang Rui, smiled at Grace at the same table, and said, "Yang Rui, otherwise, you don't spend all your time on iron ketone."

"Why?" Yang Rui asked strangely.

"Five years!" Huang Maoxu sighed and said, "Yang Rui, don't blame me for being awkward. Don't look at your high efficiency and good grades now. You think it will be like this in the future. It's impossible, you This year is 20 years old, which is the age for the most achievement. Why does our country have a juvenile class? It is the hope that the scientific research life of scientific researchers will be longer, and the research will start at the age of 20. Like you, the high-yield period can last until the age of 30. At 35 years old, even more powerful, it can last to 40 years old. In these 20 years, it has doubled the time of ordinary scientific researchers."

After a short pause, Huang Mao said again: "If you think about it, you'd better do scientific research for 20 years. Do you want to do desferiprone in five years? I'm not saying that desferiprone is not important, but just now animal experiments. , I can do it, Lao Tu can do it, and Wang Xiaoyun can do it too. Why do you waste your prime time on this, five years, how much can you do?"

Yang Rui was stunned by Huang Mao.

In his drug group, only Wang Xiaoyun, Wei Zhenxue, and Grace, who volunteered, were actually due to the relatively simple animal experimentation, and he was unwilling to waste the time of the calves who were finally brought in.

People such as Huang Mao and Li Wenqiang are all people who are able to publish cell-level articles in the future, so why use simple physical tasks?

Yang Rui had forgotten how much time he had spent with this.

After careful calculations, the entire animal experiment has only been carried out for two weeks, but for a researcher, two weeks is a lot of time.

"Just take a vacation and change your mind." Yang Rui smiled and explained to himself and Huang Mao at the same time.

Huang Mao was dumb.

Wei Zhenxue, who is sitting not far from this table~www.NovelMTL.com~, was eavesdropping with his ears erected-and only he could do this kind of thing-at this time he coughed and said, "People and people don't Similarly, some people take vacations to play outside, some take vacations to go home and sleep, and some take vacations to pull the mouse’s spine..."

"I haven't moved a single mouse." Yang Rui explained again.

"I was wrong. Some people like to watch people pull the guinea pig's spine on vacation." Wei Zhenxue laughed happily, consciously saying it was perfect.

Yang Rui was speechless, suddenly wondering if he had a tendency to pervert. After another thought, Yang Rui thought again, it's not a big deal to be invariable and not biological.

"I'll take another week off. If it doesn't work, I will consider changes." Yang Rui stood up as he said, patted Wei Zhenxue's neck gently twice, and then left it still.

Wei Zhenxue only felt goose bumps all over his body, and the warmth behind his neck was cold.

Yang Rui's thumb was placed on Wei Zhenxue's neck bone, thinking about how to speed up the progress of animal experiments.

As a simple permutation and combination of elimination experiments, the speed of animal experiments can only be changed according to the amount of resources in many cases. There is little room for technology to be used, because no matter how good the technology is, you can’t see it. The change of a compound in the human or animal body.

Don’t try, who knows how effective the compound is, whether it will be metabolized or enriched, whether the metabolic pathway is as expected, whether the metabolites are beyond imagination...

Yang Rui knew.

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