Rebirth of the God-level Xueba

eight pm.

Dean Liu came in a hurry on a bicycle and showed the work permit and letter of introduction to the police station instructor.

Li Zhangzhen is also here,

The police station instructor suddenly realized: "I said I look familiar, you are Yang Rui, I heard that you want to win the Nobel Prize?"

"Nothing." Yang Rui naturally wouldn't admit that no nomination was made.

"I'm definitely not mistaken, it's just a prize." The instructor patted his head: "Look at my dog's memory, I can't remember where the **** is buried."

Yang Rui looked at him speechlessly, and said in his heart: Eat what you buried yourself, so don't plan it out to treat you.

The aunt of the neighborhood committee was still a little unbelievable, staring at Dean Liu's work permit for a long time, and said: "Just such a young man, is it your Peking University?"

Dean Liu smiled: "Yang Rui is a student of our Peking University, so he must be a young man."

"You are so young and let out to talk to foreigners? Your heart is really big." The aunt of the neighborhood committee said, and then said: "If you talk about things, just talk about things. If you want to talk to foreigners, it's better not to find someone. Where to talk? It’s not easy to talk about, what's the point of the boasting flying all over the sky? We, China, just let you make it up and let the foreigners listen to it, hey, it’s all boasting..."

The aunt is talking about it, and Dean Liu can only listen with her neck stretched out, otherwise, what should I do? He is more fierce. He may not win. Rolling up his sleeves will definitely not work. If you find the police, the instructor of the police station is standing beside him.

After being sticky for half an hour, Yang Rui and other talents were considered free.

A few foreigners are very exciting. They all think it is a rare life experience. There is a kind of piranha who has just been swimming in the Amazon River, and has just passed through the slums of Mexico City and watched TV interviews with drug dealers. He has just boarded the plane after graffiti in Pyongyang. The joy of staring at the leader statue.

However, there is no way to continue the negotiation. In fact, it is not necessary to proceed. The conditions discussed above are also informative. In the end, whoever is willing to sign a contract, who can agree to Yang Rui's terms, or if he has to bargain, has to follow up. After that, even the CEOs and even the board of directors of the companies decide. After such a gambling agreement is negotiated, the minimum situation is to pay 1 million U.S. dollars and get nothing. It may also pay 20 million U.S. dollars or more to get more than one active substance through the clinical phase. Of course, it may also have to pay. Tens of millions or even 100 million U.S. dollars received a drug that passed the second clinical phase.

If it is $1 million, the few present can naturally decide, but everyone is not rushing to lose money. Since the amount involved in the contract may be hundreds of millions, it must be approved by a person with such authority. Naturally, it is not possible on the spot. decided. Literary age

Of course, although there was no decision on the spot, or even a paper agreement signed, everyone present was very happy.

In addition to one more experience, Yang Rui's performance also strengthened their confidence in deferiprone.

Indeed, deferiprone is not a blockbuster, let alone a big killer like penicillin. However, it is pitiful, how many people in the entire pharmaceutical industry have thought about signing a new penicillin? ——Perhaps when dreaming, everyone had such a beautiful dream, but when the dream wakes up, everyone has to face reality.

It's like architects dream of building the world's first building. You can use this as your lifelong goal. Who can sign a contract every time you do a design? That's the requirement?

By the same token, everyone knows that blockbusters sell for more than US$1 billion a year, and one can make a huge profit. You can earn money to play Porsche and Ferrari every day, but when signing a contract, you can’t just look at blockbuster bombs.

Lobster is delicious, you can't just eat lobster.

In this era when only double-digit new medicines are born in the industry every year, there are lobsters that must be caught in your hands, and steaks cannot be let go. Even if you hold the lobster in your left hand and the steak in your right hand, you will have to kick when you see the steamed buns. Step on it, otherwise, who knows if the lobster and steak are eaten, it will break, or, FD has a brainstorm and suddenly buried the lobster and steak? This kind of thing happened not once or twice, otherwise, Wall Street would not place such importance on the drug storage capacity of pharmaceutical companies.

Because of this, in this industry, original drug companies do most of the same-targeted new drugs. For example, in order to treat chronic myeloid leukemia, biologists have discovered that bcr-abl, a molecular target, may have therapeutic effects, so , The laboratories of the pharmaceutical company carried out high-throughput screening for this, found out thirty or fifty active substances, and started the animal experiment and clinical trials step by step. Finally, imatinib appeared, and it seemed to have reached the expected goal, then , Does this target complete the task?

Of course it’s impossible. This just shows that the molecular target bcr-abl is indeed as effective as biologists say. Therefore, more pharmaceutical companies will set foot in this field, so dasatinib and nilotinib have one after another. At birth, the relationship between these drugs is like the relationship between Yang Rui's last remaining seven compounds.

If all of the seven compounds made by Yang Rui pass clinical trials, in theory, seven deferiprone drugs can be produced.

In fact, pharmaceutical companies often have such a situation. It is very common for two or three compounds or even more compounds to pass clinical trials. This is not a bad thing. For pharmaceutical companies, they can choose on the one hand. The best compounds are made into drugs. On the other hand, they can also register a generic drug when the patent protection period expires, or even register multiple drugs themselves during the patent protection period, thereby occupying the market and raising the threshold. .

Because the pharmaceutical industry is profitable, even if the profit is small, it will have a profit of 20 to 30%. The advantage of the same-targeted new drug is that the risk is lower and the capital is returned quickly, so it has become the majority of pharmaceutical companies. The first choice.

Deferiprone began to be ignored, not only because of its rare drug status, which lowered its expected sales, but also because of its purely original drug status, which made it risky and slow to return funds.

The former is more difficult to change, but the latter has now been changed by Yang Rui.

The seven active substances that have passed animal experiments reduce the risk of passing clinical trials. Yang Rui is willing to sign a gambling agreement to further reduce the risk.

In fact, original drug companies are not afraid of high costs, they are more afraid of risks.

As long as the risk is low, 60 million or 100 million, I don't feel much about them.

The current cost of new drug development is steadily rising, and 230 million is normal. It was done at a very high cost. Yang Rui’s gambling agreement is actually in line with the expectations of pharmaceutical companies.

However, the gentlemen of the pharmaceutical company were happy, but Dean Liu couldn't be happy.

He handed the bike over to a Zeleca employee, got into the Zeleca car, and asked about the content of their negotiations.

Yang Rui told him selectively. Before talking about the price of the second clinical phase, Dean Liu sighed:

"I remember you asked us before, do you want to go to iron ketone? This is to go to iron ketone." Dean Liu asked regretfully.

Yang Rui nodded: "If you refuse, I will seek cooperation with Huarui Lab."

"That is to say, if we had agreed at the time, it would be possible to recover tens of millions of dollars now?"

"It's not necessarily. If you sign this agreement with me, you may not get a dime, but it is possible to get back tens of millions." The gambling agreement is not obligatory, if Peking University owns deferiprone. For patents, the most likely way to sign a contract is a milestone direct authorization, and there is a chance to recover 20 to 30 million, or 40 to 50 million.

Dean Liu selectively ignored the part of "you can't get a dime" and looked at Yang Rui with straight eyes, and said: "We missed the pcr, and we missed the iron ketone, Yang Rui, you can't do it all. Good things go to Hua Rui."

Yang Rui shrugged and said, "I have asked you both of these. You don't want me to send it to Hua Rui."

"You should persuade us more."

"No matter what I said, the funding is real. What persuades you is the funding, right?" Yang Rui said: "The PCR cost was more than one million US dollars at the beginning, and the iron ketone is higher. Now it is costly. It’s good luck. If you don’t have any luck, you will spend 20 to 30 million dollars. Peking University can’t spend so much money. I’ve got a lot of money, and the project still has to go bad.”

When doing PCR, Yang Rui made a fake inquiry. If Peking University really wanted it, he would rather drop out than give it. However, the situation of deferiprone is different. If Peking University is really willing to take this risk, Yang Rui is willing to take out deferipone. Because the risk is real, Yang Rui is not sure how long it will take before he does it, and he is not sure about the results and cost of the work~www.NovelMTL.com~ Maybe it will take one or two to make it in the end. Tens of millions of dollars in a year is also possible.

If Peking University can invest in full, it will naturally provide more professional pharmaceutical experts. Yang Rui can not only save time to do other things, but also have a lot of prestige and honor from deferiprone.

Of course, now that things are done, it's useless for Dean Liu to say anything.

Dean Liu himself knew this, shook his head, and said, "No, if you have a new project, you have to tell us well."

"That's for sure." Yang Rui said frankly, and then asked again: "Can you stand a project that requires more funding?"

"How much to see in detail." When it comes to funding, Dean Liu is still a little frustrated.

"Didn't you just say it?"

"You just talked about the negotiation, the cause and effect, you didn't talk about the specific research."

"Ah...how long does that have to be said?"

"No hurry, let's go back and talk slowly." Dean Liu said, patting the back of the driver in front of him, and said: "Go to Peking University."

"Now?" Yang Rui looked at his watch, and it was past 8 o'clock in the evening.

Dean Liu said unambiguously: "Go, Academician Cai and they are all waiting. We are just getting started in the area of ​​new drug research."

With that said, Dean Liu glanced up and down Yang Rui with his eyes.

Yang Rui was swept uncomfortable, and asked: "You can't wait in the office, right? When I call you, you will be off work."

"It's off work. People are gathering at Academician Cai's house. Sister-in-law is cooking. Let's drive faster and mix some soup." Dean Liu said and urged the driver.

.............