Black technology, starting from daily check-in

Office of the Chairman.

"Phew...it's finally over."

After signing the last agreement in his hand, Lin Yu casually threw it on the table, let out a long sigh of relief, lay softly on the sofa, and said with a sigh: "The acquisition of the company is really troublesome. If I knew it earlier, I would let Li Xuan handle it." gone."

Baiji's market valuation is currently around 50 billion, and the amount required for the acquisition is relatively large, so she handed over with Baiji's finance department.

Otherwise, how could Lin Yu do those tedious things here.

Hearing Lin Yu's complaints, Ouyang Lei, who was handling the agreement on the side, said dumbfoundedly: "You just took office and found it troublesome. What will you do in the future?"

"Isn't there still your hard-working employees?"

Lin Yu waved his hand and said indifferently.

Hearing that, Ouyang Lei was also a little helpless, as soon as someone else became the chairman, he would use all kinds of threats to look for opportunities to improve his prestige.

As it turned out, this guy in my family was fine, as soon as he took office, he wanted to be the hands-off shopkeeper...

Leaning on the sofa with his eyes closed, Lin Yu checked his page in his mind.

【Host】: Lin Yu

[Skills]: Speed ​​reading shorthand, mastery, cooking skills... (expand)

[Number of check-ins today]: 1

[Today's rebate times]: 3

After finding out that he still had one sign-in and three rebates today, Lin Yu didn't think much about it and planned to use them up directly.

As the system's notification sounded, a familiar voice came.

[Ding, you have successfully signed in Baiji Biotechnology Co., Ltd., and you will be rewarded with CAR-T cell therapy technology! 】

[Ding, the host can currently sign in: 0]

Before Lin Yu could react, the familiar white space reappeared in a trance.

A second later, Lin Yu opened his eyes suddenly, and a huge surprise flashed in his eyes.

Just now, he has almost completely mastered CAR-T cell therapy technology!

Even Lin Yu is very excited about the emergence of this technology, because it is simply too powerful!

What is CAR-T cell therapy technology?

In simple terms, it is a method of personalized immunotherapy that can specifically remove specific cells in the body.

In other words, it is a huge lethal weapon that specifically fights against tumor cells. It is an anticancer drug, and it is still very powerful.

This method is mainly to carry out genetic engineering modification on the patient's T cells, add a chimeric protein on its surface, and then expand and activate in vitro, and then transport it back to the human body.

The enhanced T cells can acquire the ability to recognize tumor cells through the single-chain antibody of the chimeric protein on the surface, and activate the co-exciting part of the chimeric protein, triggering a cellular immune response, thereby destroying the tumor target cells!

From the perspective of weapons, this CAR-T cell therapy technology is equivalent to transplanting the T cell shells from the body, and then artificially upgrading them into strategic missiles.

By the way, a precise strike and precise navigation system was set up for the strengthened T cells (missiles), which can directly strike tumor target cells from the source, a powerful batch.

As for why Lin Yu said that this cell therapy technology is powerful, it is because it can prolong the survival period of about 3 years after one use, even for people with advanced cancer.

In game terms, that is to directly add three years to your life expectancy!It is not an exaggeration to say that it is an "anti-cancer elixir"!

According to the information Lin Yu learned from reading, the number of new cancers in China is 457 million, accounting for 23.7% of the number of new cancers in the world

Because China has a relatively high population base, it is the country with the largest number of new cancer cases in the world. Just last year alone, there were as many as 300 million patients who died of cancer in China.

Including the number of new cancers and the number of people living with cancer, the number of cancer patients in China is at least 2000 million.

In other words, nearly 2000 million patients are waiting for anticancer drugs every day.Some are unaffordable, and some have no medicine...

Thinking of this, Lin Yu felt inexplicably anxious.

The BTK inhibitor and CAR-T cell therapy technology must be developed as soon as possible, and then applied for marketing, so that more Chinese can enjoy low-cost anticancer drugs!

Controlling the mobile phone, Lin Yu used up all the three rebate opportunities today. Lin Yu handed over all the 392 billion obtained to Li Xuan, and left 224 billion in the account for tomorrow.

After finishing all this, Lin Yu looked directly at Ouyang Lei who had finished the agreement, and asked, "Lao Lei, how far is our company's research and development center for anticancer drugs from here?"

Through the previous acquisition agreement, he has learned that Baiji is focused on developing and innovating affordable drugs.

Moreover, Baiji is at the forefront of China in the discovery, development and innovation of targeted tumor immune drugs and the treatment of cancer.

This is also the reason why they are short of capital chain.

Because the research and development of each anticancer drug is very expensive, and even 5000 million can be burned in a day, which is very exaggerated.

"what?"

Hearing Lin Yu's leap-forward question, Ouyang Lei froze for a moment. It seemed that he was not very used to the name "Old Lei". It will arrive soon in about an hour..."

"Okay, let's go, let's go there and have a look."

Lin Yu nodded, got up and said, "Regarding the research and development of anticancer drugs, I have some ideas that I want to practice recently to see if they can help the company's research team."

Listening to the meaning contained in Lin Yu's words, Ouyang Lei almost froze in place.

The development of anticancer drugs?Idea to practice? ?

The newly appointed chairman of the company is actually a researcher of anticancer drugs? !

This world is too crazy, such outrageous things can still happen in front of him.

And you, a boss with billions of dollars, is always a grassroots researcher. I'm afraid no one will believe it when you say it.

However, thinking that Lin Yu came here by taxi when he first appeared, Ouyang Lei suddenly understood.

His chairman may be different from other bosses. In terms of behavior, he may have a more...um...distinctive personality.

Keeping these thoughts secretly in his heart, Ouyang Lei soon began to make arrangements, and by the way, asked someone to say hello to the R&D center in advance.

At present, the layout of Baiji Company is mainly composed of four major parts in terms of disease areas, namely the field of solid tumors, hematological tumors, tumor immunity and autoimmune diseases.

Each of these parts accounts for about 25% of the total, and each has a dedicated R&D center.

After all, Baiji Company also relies on drugs to make money. Although it is not enough to make ends meet now, it can still spend less money anyway.

Soon, under the leadership of Ouyang Lei, the two drove to one of the four major research and development centers under the name of Baiji Company.

Along the way, Lin Yu also learned about the status of the R&D center from Ouyang Lei.

It turns out that their current research direction is the antigen receptor of B cells, Bruton's tyrosine kinase (BTK).

In other words, they are now working on BTK inhibitors, but they haven't been successful yet, but they have already got a glimpse, and they have a glimpse of the door.

The reason why the capital chain was tight before was because this research and development project was in a stage of rapid development and required crazy money burning.

Because BTK inhibitors have become popular targets for the treatment of hematological malignancies and autoimmune disorders.

As long as it can be successfully developed, the situation that the entire Huaxia anti-cancer market can only enter and cannot be entered will be completely broken, and the research and development company can also obtain huge benefits.

It can be said that it is a good thing to gain both fame and fortune, so those pharmaceutical companies feel that no matter how much they pay, it is worth it.

This is also the direction that all pharmaceutical companies are now working together. Whoever can come out on top will be able to occupy the Huaxia anti-cancer market and expand foreign markets!

Because cancer is not only found in China, it is found in almost every country in the world.

And all cancer patients are eager for new anticancer drugs to appear as soon as possible.

When the two arrived at the R&D center, Amy, the head of the R&D center for blood tumors, had already been waiting at the door for a long time with management staff.

Looking at the leader, Lin Yu recognized at a glance that this was one of the foreigners who had dinner together at noon.

Well, that's right, that middle-aged foreign man who sees him like a pervert sees a peerless beauty.

"Oh, look who this is, my dear chairman, it is our honor for you to visit the R&D center." Amy looked at Lin Yu with fiery eyes and said enthusiastically.

Lin Yu has no choice but to hear this damn translation accent, which is really uncomfortable.

Ouyang Lei introduced with a smile, "Chairman, this is the Chief Medical Officer of Hematology and Oncology of Baiji Company, Amy Peterpat, who is also the person in charge here."

"Well, hello, Amy."

Lin Yu responded lightly, and said straight to the point: "Please take me to the research room directly. I have some research ideas about anticancer drugs that need to be verified."

Amy was shocked by Lin Yu's words: "My God! It's incredible that our chairman is still a great scientific researcher!"

Lin Yu: "..."

If it weren't for the fact that he was a foreigner, Lin Yu seriously suspected that it was because of himself.

After a short greeting, Lin Yu followed Amy for more than ten minutes, and finally came to the outside of the research room of the BTK inhibitor in the R&D center.

Through the glass, Lin Yu can clearly see the situation inside.

Here, hundreds of professional team members are wearing white masks and work clothes, sitting at their work posts, staring at the glass test tubes, liquid tubes and other experimental devices in their hands seriously, and repeating the work in hand

"What stage is the research on BTK inhibitors now?"

Lin Yu asked while watching the researchers' operations inside.

"Regarding the research on new drugs, we have now found the target, determined the model, and are currently looking for lead compounds."

Speaking of her professional field, Amy said with a serious expression: "As long as a large amount of funds is injected, we will be able to find suitable lead compounds in a short period of time, and then optimize them, and soon we will be able to carry out in vitro experiments and animal experiments. , human experimentation, and it will be on the market at that time."

Hearing this, Lin Yu looked away from the researcher and glanced at him lightly, a little speechless.

Do you look like someone who is easy to fool?

Why did he think of asking him to invest and contribute money when he came here? He really thought he was being taken advantage of.

Moreover, with the current research progress, even the lead compound has not been found, let alone the optimization of the lead compound and the subsequent in vitro experiments.

If I don't come here, I'm afraid I won't make breakthrough progress in a few years, because the progress is too slow.

But this is normal, after all, the research of new drugs is very troublesome.

This is like giving you the manufacturing process and drawings of a pistol, but you even need to find the raw materials of gunpowder from countless materials one by one.

However, after you find it, you still need to match it, so you have to continue optimizing on the basis of the original material until it becomes real gunpowder.

It takes such a long time to make a single gunpowder,

It is conceivable how tedious and complicated work the whole is.

"Go prepare your overalls and research tools, and I'll go in and test my research ideas."

After thinking about it, Lin Yu said seriously: "If it succeeds, the lead compound of the BTK inhibitor can be found and optimized today, and then you can directly conduct in vitro experiments and animal experiments. Of course, remember to do a good job in confidentiality. .”

As soon as these words came out, Ouyang Lei and Amy froze in place.

Can you find a lead compound and optimize it if your research idea is successful?

I'm afraid I'm not joking, how could such a thing happen.

However, looking at Lin Yu's serious look, which doesn't look like a joke, Ouyang Lei and Amy looked at each other, not knowing what to say for a while.

If lead compounds are really so easy to find and optimize, then hundreds of them still need to analyze, screen, and research here day and night?

If the chairman of the company can really successfully find and optimize the lead compound, then hundreds of them can pack up and go home to raise pigs.

Just kidding, how could the efforts of their professional team of hundreds of people be inferior to Lin Yu's ideas alone?

This is impossible, absolutely impossible!

Unless he cheats!

However, even if they don't think Lin Yu can succeed, they still follow the instructions of their chairman.

Soon, under the arrangement of the two, Lin Yu put on a mask, a white research uniform and blue rubber gloves, and walked into the laboratory.

Standing at his own work station, looking at the glass tools, bottles and cans, as well as various electronic instruments in front of him, Lin Yu felt an inexplicable sense of comfort in his heart.

It was as if he had returned home. He was very familiar with and proficient in all kinds of tools and instruments.

It's a wonderful feeling.

Soon, as time passed, Lin Yu began to gradually enter the state, manipulating the tools in his hand with a focused and serious expression.

The research of a new drug is not easy, it requires strict and complicated steps, a long process and a lot of money.

First of all, it is necessary to define and classify new drugs, and then clarify where the drugs work.

Simply put, where the virus wants to go in the human body, the role of the drug is to prevent it from going there.

Usually, viruses go through the process of adsorption, penetration, shelling, biosynthesis, assembly and release in the human body.

Each of these stages may be a place where the drug works, and this place is called a target.

Once the target is determined and the model is established, the second step is to find the "weapon" that can act on it, that is, the lead compound.

A lead compound is a molecule, and there are many ways to find it, such as screening from drugs, screening from natural products, gene synthesis, chemical extraction, and so on.

After a series of experiments found that it is useful, it will be made into medicine.

The third step is through in vitro experiments, that is, experiments on non-biological organisms such as proteins, cells, and tissues.

After preliminary verification of the drug efficacy, continue to optimize the lead compound to make it safer, more effective, and ideal.

The time spent at this stage cannot be determined at all, because it is full of unknowns.

But generally speaking, it takes a long time, and it can't be done for a few years.

And then it's simple, you only need to conduct animal experiments, and then continue to collect data in the blood, urine, and feces of the animals until the data of this new drug is at a stable and normal threshold.

Finally, there are human experiments, which are the same as animal experiments, but more rigorous and pay more attention to safety.

Whenever there is a little bad sign, the drug dosage will be recalculated until it is safe and correct.

It takes at least ten years, or even a little longer, to develop a new drug.

But it's different now, because Lin Yu already has a finished product in his mind.

Where is the lead compound? He can quickly find it, and he can quickly optimize it to the ideal shape in his memory.

To put it bluntly, Lin Yu seems to be overlooking everything from the perspective of God.

When others are still having a headache about the complex topic of lead compounds, he has already found the answer when he saw the topic at first glance!

That's right, it's such an exaggeration!