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Chapter 151 – In vitro kidney cultivation

Xie Ziqian originally had a few meetings to be held. Hearing Di Jingwu’s words, he rushed to the laboratory immediately.

“Where? Let me see!” Xie Ziqian said.

“This is the image under the electron microscope!” Di Jingwu opened the computer page and opened it to him.

“There are also image comparisons from the previous few days. At first, these were just a group of mouse stem cells. After a few days of division and differentiation, they have now begun to develop in the direction of the kidney organs!” Di Jingwu said.

“My God, did he really do it?” Xie Ziqian had never been so surprised, including him, no one would think Du Xingyu’s experiment would be successful.

If his in vitro organ cultivation is successful, it will definitely be a technological invention that changes the world! What about the Nobel Prize in Medicine, the Galdner Prize in Medicine? I’m afraid to get soft!

This is a technological discovery that can benefit all mankind, and it has now revealed its embryonic form!

“How did it do it? How did the differentiation succeed in vitro? Why do these kidney cells survive in the in vitro environment? How did he design this culture device?” Xie Ziqian asked.

“Um…” Di Jingwu said in a little embarrassment, “I didn’t understand. Everyone is busy growing epithelial cells, and they don’t pay much attention. Most of them are done by himself.”

He didn’t say a word, because everyone in the research group thought Du Xingyu was wasting time, so he was not interested and used their energy on their original research goals.

“No, I have to find it!” Xie Ziqian has realized the importance of this matter, this is a biological science discovery that can change the world!

He immediately called Du Xingyu and said excitedly: “Little Du, in your petri dish, the stem cells have successfully differentiated! We have just observed that the stem cells are beginning to differentiate into the kidney!”

“Almost.” Du Xingyu replied with an “unsurprisingly” tone, “It should start to differentiate today.”

“You must not be excited?” Xie Ziqian wondered, “Achieving this step has already shaken the biological sciences and medical circles!”

“It’s okay.” Du Xingyu said, “The experiment has just begun. Whether the kidney can mature in the in vitro environment or whether the transplant will be successful is still unknown. Besides, even if they are all successful, it is only a mouse experiment. The stage of human trials.”

Xie Ziqian said with emotion: “It’s really weird to be so calm and calm at your age.”

“Anyway, this is a good start!”

“Next we will do our best to study this project!”

Xie Ziqian immediately notified all members of the team that after learning that Du Xingyu had directed the differentiation of mouse stem cells into kidney cells, all members had a refreshed world view.

“Can he really do it? This is a wizard!”

“I thought it was a joke at first, this can be done…”

“The young people nowadays are incredible!”

“How does his brain grow? How can he be so much smarter than us?”

Now, no one dares to underestimate Du Xingyu’s words, because they know. The discovery of Du Xingyu’s directed induction of mouse stem cells to differentiate into kidney tissue alone surpassed their lifetime research results!

The laboratory did not announce the news immediately, because they were still waiting, wondering if the kidneys of these mice could be used for organ transplantation.

After 30 days of cultivation, ten mouse kidneys have been grown in the mouse kidney cultivation device. They are derived from different mouse stem cells.

The owners of these stem cells have grown into mature mice and can be used for experiments.

“Today, we are going to perform a mouse organ transplant!” In the laboratory, Xie Ziqian and others looked serious.

They are all veteran experts. Let alone the mouse experiment, they don’t know how many times they have undergone operations on humans, but this time they seem extremely nervous.

Because the organ to be transplanted this time was cultivated in vitro by Du Xingyu! The meaning is extraordinary!

After being anesthetized, ten mice lay on the operating table, waiting for an organ transplant.(Read more @ wuxiax.com)

The operation was performed by Jing Jian, the most professional surgeon, and he spent 120 minutes of attention.

“It’s done!” After the operation was completed, Jing Jianchang exhaled. He hadn’t been so nervous for a long time.

“At present, the vital signs of mice are stable, and there are no abnormal reactions for the time being.”

“Continue to observe and see if these cultivated kidneys are really useful!”

These ten little white mice have become the “objects” of everyone’s attention. Their physical health affects everyone’s heart.

In the first few days, the mice were recuperating and recovering from the surgical trauma.

After a period of time, the mice were basically healed from their injuries, and they were already able to jump around, and some of them were even able to engage in mating behavior.

“The target physiological performance of organ transplantation is very good.” At the research group meeting, Du Xingyu said, “This is also the same as I imagined at the beginning, because the stem cells are taken out of themselves, so there is no excretion of organs. Allergic reactions. The functions of the transplanted kidney are relatively normal.”

“The first stage of this experiment should be considered a success.”

After Du Xingyu finished speaking, there was warm applause in the conference room. Everyone was extremely happy. Before Du Xingyu joined the research project, they never thought they could do this!

Now, as long as the success of their mouse research is announced to the world, biologists and medical scientists all over the world will surely be amazed!

“Unexpected!” Xie Ziqian smiled, “I really didn’t expect the mouse experiment to be so successful. It seems that asking Xiao Du to join our research group is the wisest choice.”

“Yes, we should be the first team in the world to successfully cultivate mouse organs in vitro!”

“This discovery is too important. This will help us cultivate human organs and accumulate experience!”

“Don’t worry about the academic exchanges in the future.”

Du Xingyu asked: “Director, when can we start human organ cultivation experiments?”

Xie Ziqian has already thought about this issue. He said: “Under normal circumstances, I don’t recommend that human organ cultivation experiments be carried out so early. However, our first phase is so smooth, so it is the wisest choice to start human organ cultivation experiments as soon as possible. ”

“We achieved results a day earlier, and millions of patients in the world who need organ transplants can get the hope of rebirth.”

“So, I will arrange this as soon as possible.”

To start the in vitro cultivation test of human organs, some advantageous procedures are needed. Thanks to Xie Ziqian’s efforts, they quickly obtained approval, and one patient was willing to participate in medical trials.

“Sun Dahai, male, 45 years old. The end of chronic renal failure has reached the stage of uremia, and kidney transplantation is necessary.”

“But for more than a year, no suitable kidney source has been found across the country. If kidney transplantation is not performed as soon as possible, it will be difficult for patients to survive.”

“His family members have signed a voluntary participation in medical research trials, and nurturing his kidneys is our goal in the next phase.” Xie Ziqian announced the goals of the second phase of the trial.

Du Xingyu has also seen the patient’s information. This patient is an ordinary truck driver, the head of the family, who is old at the top and young at the bottom, suffering from chronic renal failure, exhausting his family’s wealth, and it is not helpful.

Across the country, there are about 150 patients who need a kidney transplant, and only one person can get a chance for a kidney transplant!

And it’s just an opportunity. Among them, only a few people can transplant successfully. Even if the transplant is successful, it is necessary to constantly take drugs to resist rejection…

“The first step to transform mankind is to start with organ cultivation.” Du Xingyu thought.

He began to research according to the results he got on the simulator.

In the first step, Du Xingyu must first obtain Sun Dahai’s related stem cells before he can induce differentiation.

Fortunately, Du Xingyu has already had the experience of obtaining Tyrannosaurus rex stem cells.

The second step is to induce stem cells to differentiate into kidney organs and culture them in an in vitro device.

In mice, they have already completed this process. But this time it was a human organ, and no one dared to say that he would be successful.

…

The development of human organs is much slower than that of mice, but patients cannot wait that long. Therefore, during the breeding process, the team used hormones to stimulate organ development, which may result in the kidney’s lifespan being lower than that of a normally developed kidney.

But the patient is over forty years old, and the “lifespan” of the cultivated external kidney must be longer than the lifespan of his normal kidney now!

Day by day, in the in vitro cultivating device designed by Du Xingyu, a human kidney is connected to various artificial physiological “organs” and develops rapidly.

…

“In one month, the kidneys we cultivated will probably be mature enough for surgery.” In the doctor’s office of the Peking University Affiliated Hospital, the attending doctor Tong Kai said to Sun Dahai’s family.

“Doctor, is it really okay?” Although he had asked many times, Zhao Fang, Sun Dahai’s mother, asked.

This is related to her son’s life, even if she asks ten thousand times, she feels less.

Looking at the worried and pleading eyes of the patient’s family, Tong Kai comforted: “I can’t guarantee the absolute success of the operation. But I asked the director. The trial is going well and the probability of success is high.”

“As a family member, you should also stabilize your emotions, so that the patient’s emotions are also stable, which is more suitable for surgery.”

“Thank you doctor!” Sun Dahai’s parents can only pray silently in their hearts, this time a brand new medical technology will be born.

There are only less than ten days left before the organ transplant operation.

Several foreign teams that originally worked with Xie Ziqian’s team to conduct research on in vitro organs (mainly skin tissue) were also invited to the Affiliated Hospital of Peking University for academic exchanges.

Before their arrival, these teams have achieved certain results and have been announced. So when these foreign experts came, they were somewhat proud of them.