Rebirth of the God-level Xueba

In the laboratory, Yang Rui touched his head and wrote a note on the paper, thinking about the next experiment goal. It seemed idle, but in fact his brain was working violently.

Instead, Huang Mao and others worked conscientiously in front of the test bench, busy re-verifying the data to complete the minor revision of the paper.

The relationship between the experimental dog and the researcher is almost exactly the same as the relationship between the dog and the man who throws the frisbee and walks the dog in the park.

If the cynical experimental dog sees this familiar scene, he will definitely talk about laboratory exploitation.

However, normal laboratories operate in this way.

And the more high-end laboratories, the pure hard work and hard work, the less meaningful it is.

As the person in charge of the laboratory, Yang Rui's work in the laboratory is mainly to ask questions.

Asking questions here is actually to synthesize existing scientific research results, especially the hotspots of scientific frontiers, and put forward your own hypotheses or ideas.

For example, in the study of potassium channels, Yang Rui put forward the hypothesis that the structure and properties of ion channels can be verified by cloning mutant genes.

This can be said to be a very difficult and wide-ranging hypothesis. In order to realize it, Yang Rui put forward the second level of hypothesis: we can target the genes that we want to mutate.

Similarly, in the second level of vision, Yang Rui has further refined ideas, such as: targeted mutagenesis of organisms, preferably fruit flies.

This step-by-step assumptions and hypotheses seem easy, but they are actually difficult. It is also the first condition for whether they can become the person in charge of the laboratory.

The work of Huang Mao and others is actually solving problems and completing Yang Rui's assumptions and assumptions.

In order to complete their work, Huang Mao and others have to put forward their own assumptions. This is also a self-training for them. The better a researcher you do, the faster you can get out of it.

As far as natural science is concerned, assumptions and hypotheses must be built on a solid foundation, that is, the pre-research results have already been produced.

Of course, how strong it is and how much it is installed depends on the level of the proponent.

If the level is low, you can stand on a solid foundation obediently and do the work that can be done with your hands, giving human civilization an impenetrable power to move forward.

If the level is high, the requirements for pre-research results will be low.

A classic example is the Manhattan Project for building the atomic bomb. At the level of Oppenheimer at the time, he was not qualified to put forward this idea and hypothesis. The leader who wrote to Roosevelt was Einstein, and he must also be Einstein. In the case of nothing, even a little experimental proof, start such a project.

In fact, it was scientists from Europe who rushed to promote this project. They persuaded Einstein to have a letter to Roosevelt.

Otherwise, according to the normal research model, the Manhattan Project can wait for twenty years of pre-research slowly, at least until someone can make the enriched uranium before it has the basis for a nuclear bomb.

But because of the state of war and because of Einstein's presence, the prerequisites for the Manhattan Project have become lower.

Instead, the project got bigger.

Yang Rui is considering how big and how big his new project can be.

What he wants to do most now is technology.

According to the timeline, the original author, Mouris, should now start to consider the relevant ideas.

However, Mouris is a well-known slacker, in a better way, it is free and forthright.

Therefore, despite the relevant ideas, the development is not too difficult. Mulic still took more than two years, and it was only partially completed around 86, and it would take 87 years to complete it completely.

It is safer to do it now. However, Yang Rui only has an unpublished "Cell", and he immediately marches into it. It is no problem to make it, but he is not sure whether he can get the corresponding reputation.

Although the scientific community is a place where results are spoken, the scientific community is after all a collection of people. There are not a few researchers who have received too much praise or have not received the rewards they deserve. Some of them, in the next In the past few years, he has been recognized and even compensated, but some people may be completely buried in the pile of old papers.

The Moussian is really lazy, but the company behind him is not. On the contrary, next year, after the company has determined the certainty, it has invested a lot of resources for this, including many excellent researchers. Deputy.

After thinking about it, Yang Rui decided to seize a favorable position first.

Although he does not have the corresponding prestige, it is very likely that he will not get the Nobel Prize-but who is sure to get the Nobel Prize.

Einstein almost missed the Nobel Prize because of the unproven theory of relativity, and finally had to use the photoelectric effect to award the prize.

With a small body like Yang Rui, or, in other words, with a small body like Mouris, it really depends on whether he can win a prize.

Since it is a matter of life, suffering is meaningless.

Yang Rui thought of this, and began to slowly write down a few key points on the paper.

For the same project, Yang Rui did not intend to repeat the steps of Mouris back then. To be precise, he could not repeat the steps of Mouris back then.

Because in the final analysis, it is just a layer of window paper, which is easy to pierce but not easy to tear clean.

Yang Rui didn't want to poke a hole and then attract a pack of wolves.

Although it is likely to be caught in the scientific research competition again, from Yang Rui's point of view, he still hopes that the scientific research competition will happen as soon as possible.

There is no biotech company with assets of more than 100 million yuan behind him to provide support.

The most ideal way is when Yang Rui has established an unrivaled advantage, and later competitors will not have large laboratories participating in the competition out of cost-benefit considerations. As for the scientific research apes who are always staring at the hot spots to do experiments, it is impossible to stop them. These scientific research apes are all scavengers, but they do not affect the work of the main laboratory.

"Then, let's start with the heat-resistant polymerase." Yang Rui focused his eyes on the last step.

Although it is the last step, heat-resistant polymerase is the pre-technology of practical technology, and it is also a necessary material. Making it in advance can speed up subsequent research and development and reduce costs.

On the other hand, this is a very critical technology, and as early as 1973, there was related research.

Before the technology was released, the technology was not taken seriously, because people also knew what it could be used for, and the researchers themselves did it out of interest. In 1973, female students from Taiwan, at the request of the instructor, The thermophilic bacteria found in the hot springs of Yellowstone Park was the subject of research, and the high-temperature resistant taqdna polymerase of the bacteria was successfully isolated. Yang Rui didn't even know whether she had applied for a patent.

At the time, it seemed that this might be quite unnecessary. No one could have imagined that this would eventually become a key part of a technology worth 300 million US dollars.

However, even if the other party does not have a registered patent, but has a paper in hand, it is not allowed to preemptively register. Yang Rui's brains are turning quickly, and he immediately thought of a new method: find a new thermophilic bacteria as a research object, and use a new method. Separate high-temperature polymerase.

Two researchers can apply for a patent if they complete their own research, which is also a conventional method to bypass patent barriers.

Yang Rui then searched for related papers in his mind.

Thermophilic bacteria are microorganisms that live in high temperatures. There are many types. There are also specialized researchers and laboratories to do related research. If Yang Rui plunges into it without preparation, he will probably not get out of it for a lifetime.

He must find a thermophilic bacteria that has been studied thoroughly, determine that it can be used for the separation of high-temperature polymerases, and then start related projects~www.NovelMTL.com~ As far as the current scale of the Huarui laboratory is concerned, it is not qualified to be as top-notch Like the laboratory, do a wild and money-burning trial and error method.

Ten minutes later, Yang Rui wrote "Tengchong" heavily in his notes.

The handwriting is dark and thick.

The thermophilic anaerobe in Tengchong Hot Spring is the first extremely thermophilic bacteria discovered in China. After being discovered in 1998, Chinese scientists have done whole-genome DNA sequencing, and it has become the first genetic code in China to decipher the genetic code. microorganism.

In the Chinese biological world, Tengchong thermophilic bacteria can be regarded as a famous bacteria. Yang Rui has various studies on this microorganism in his mind, such as archaeal chromosome proteins, new mechanisms of bacterial spore formation, and isolated extreme enzymes...

It couldn't be more natural to use it to separate high-temperature polymerases.

"Let's go to the hot springs." Yang Rui looked up suddenly, her eyes shining.

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