Rebirth of the God-level Xueba

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　　 The DNA synthesizer used to produce oligonucleotides was delivered from Tianjin Port within a few days.

　　 Yang Rui also confirmed the arrival of these basic equipment before starting the formal project.

Unlike the happy Mouris, Yang Rui is first not white, second is not American, third is not a member of well-known research institutions in developed countries, fourth has no educational background from well-known European and American colleges, and fifth has no major company or institution background , The sixth year is too young.

　　 Under such circumstances, to win the Nobel Prize, Yang Rui must first have excellent results.

The results of 　　 are naturally very strong, but for the Nobel Prize, there is no strongest but stronger.

　　 Secondly, Yang Rui had to be cautious, step by step.

　　 The carefulness of scientific research is not a multi-party verification of the results. Multi-party verification. Naturally, other scholars will do these things for you. Repeat the experiment so that you can publish the paper, because the repeated experiment has a certain value.

　　 The careful scientific research is to publish papers in stages.

　　 Historically, Mouris and his company have published about three papers in total. They are large American companies. Publishing a paper at a large stage can prove their work.

　　 For Yang Rui, it's not so easy to handle.

　　 He still has a CELL-level paper, which is very rare in China, but internationally, this is the basis of the stepping stone, and the effect is better than an unknown PHD (Ph.D.).

　　On this basis, Yang Rui plans to publish a paper with a double-digit goal.

　　 His reference object is the research group of synthetic bovine insulin in China. This research group has published more than 20 papers in a number of top journals for several years, proving the attribution of the results with a very clear research chain, and at the same time gradually igniting the topic.

　　 Although the Chinese research group in the 1960s was at the national level, it had to prove itself and faced a lot of problems. Yang Rui now has Peking University endorsing his identity and CELL-level papers. The degree of difficulty is about the same as the research group of synthetic bovine insulin back then.

　　 However, to form a clear research chain, it is not necessary to write everything, nor to publish papers in chronological order.

　　 For example, heat-resistant polymerase, Yang Rui is going to publish it at the end.

　　The reason is very simple, there is a heat-resistant polymerase, which can greatly reduce the experiment time.

　　 is essentially a DNA multiplication technology.

　　 It can quickly double, then double, and double the DNA...In theory, you can double as many times as you want.

　　 This is like the story of the famous standard bearer and the king.

　　 Put 2 grains of wheat in the first square of chess, 4 grains in the second square, 8 grains in the third square, 16 grains in the fourth square, and so on, how many grains are there in the 30th square?

　　——The 30th grid will have 1,073,000,741,824 grains of wheat.

　　 also showed his skills in countless fields because of this super multiplication technique.

　　 For example, DNA residues at crime scenes. Before the times, too few reagent residues could not be detected, but since the 1990s, the police stations that have owned them can ignore the number of residues. In theory, as long as there is a complete DNA residue, it can be multiplied to a detectable state.

　　The reason why it was only owned by the police in the 1990s is because of the heat-resistant polymerase.

The raw material is polymerase, ordinary polymerase can also be used, but every time it is doubled, the heat-labile polymerase will be inactivated in a water bath with a temperature of more than 90 degrees. When the second time is doubled, it will have to be Add polymerase once.

　　 Polymerase is not cheap, not to mention, this process still needs professionals to do, it is complicated and error-prone.

　　 In the research process, adding polymerase 30 times in succession is also not an easy task.

　　Of course, it is not easy to develop a heat-resistant polymerase.

　　 Therefore, in history, Murris and others first worked to solve the problem of doubling, and did not give priority to the problem of heat-resistant polymerase.

　　 After all, only when the doubling problem is solved and the method is proved feasible, is it necessary to simplify the method.

　　 Otherwise, the heat-resistant polymerase alone, without the technology to use it, is also useless.

　　 However, Yang Rui is different from Mouris and others.

　　 He knows with certainty that it is a good technique.

　　 Therefore, he is the first to do research that can improve efficiency. When he wants to release the paper in stages, even if others are inspired, they can't keep up with his speed.

　　 In fact, Yang Rui still hopes that someone can chase behind his ass.

　　 If a Chinese person simply makes a smart, simple, and world-influencing achievement, half of the evaluation he gets is estimated to be "lucky luck."

　　 But if a Chinese, in the scientific research competition where you are chasing me, uses a clever and simple way to make a result that affects the world, his evaluation must be very different.

　　 Of course, there must be risks in doing so. But Yang Rui thought about it and decided to publish the paper in stages.

　　The reason is very simple. A simple paper will not necessarily send Yang Rui to the altar of the Nobel Prize.

　　 If there is no Nobel Prize, the value of the project will be greatly reduced. Although it may still be worth 3 billion U.S. dollars, to Yang Rui, the value of the Nobel Prize is more than 3 billion U.S. dollars.

　　 In this line of thinking, on the fourth day after the delivery of the DNA synthesizer, Yang Rui began to draft the first paper-"Improvement Ideas for the DNA Synthesizer."

　　 is still a prologue paper, and can only be said to be a prologue of a prologue, but the so-called scientific research chain is such a chain of links.

　　 Huang Mao and others are very happy. They have just signed a thick legal document written by a number of lawyers from Hong Kong, and they have almost given all the rights to Huarui, leaving only one signature right.

　　 The Chinese in the 1980s never made money through patents or similar means. Huang Mao and others didn't care about it. What they care about is more reputation.

　　Fame is naturally to be piled up one by one.

　　 According to the DNA synthesizer commonly used in later generations, Yang Rui picked some casually and used it on his newly bought DNA synthesizer.

　　 The newly recruited Maverick Zhang Xuetong was born in engineering, and the two teachers from the Department of Mechatronics, whom Yang Rui paid for, simply modified most of the DNA synthesizer. The domestic environment is like this. Refitting old instruments and synthesizing broken instruments is the mainstream. There are many scientific researchers who do not understand English and have little practical ability.

　　 Local tyrants like Yang Rui can only be seen in domestic academician-level laboratories.

　　 280,000 U.S. dollars, but it's about to catch up with the assets of the laboratory that Tang has managed for many years, that is, the academician-level laboratory is worthy.

　　 However, Yang Rui’s ideas written in the new paper require not only hands-on skills, but also considerable materials and parts. Zhang Xuetong has no choice but to find things that cannot be found in China.

　　 Yang Rui has a good way to do this. When sending the paper to the journal, he also sends a copy to the company "Bio Research", the company that produces the DNA synthesizer.

　　 Zhang Xuetong was a little uneasy about this, and asked: "This biological research company, will it plagiarize our technology?"

"Generally speaking, no. They don't know what evidence we have left. For example, the photos I just took are our evidence. If they plagiarize, we can not only sue them, but also scold them in the circle... "Yang Rui said with a smile, and said: "It is not easy to be a biological company. We have also kindly helped them make technical improvements. This level of transformation does not require plagiarism."

　　 "We're doing an international live Lei Feng." Zhang Xuetong looked a bit ugly, but after modifying it himself, the DNA synthesizer with more complete functions gave a sense of accomplishment.

　　 Yang Rui nodded slightly, but said: "We are good people, yes, it may not be necessary to live Lei Feng."

　　 Zhang Xuetong frowned like a plus, and said, "We are not doing well enough, and the international standards of Huo Leifeng are too strict!"

　　 Huang Mao, who had been to the United States, couldn’t help but laugh. He and Yang Rui were already familiar, and said: “I guess what Yang Rui meant is not to give away other people’s technology for nothing.”

　　 Zhang Xuetong was puzzled: "The technology is improved on other people's machines. What if we don't send it out? Let's improve and sell it ourselves?"

"Where do we have time to sell." Huang Mao glanced at Yang Rui, and when he saw that he didn't say anything, he knew that he had guessed it correctly. He said happily, "Lao Mei's current technology companies are very accustomed to this kind of technological improvement, especially The first-generation instrument, you see that it is so expensive, that it is expensive in R&D costs. If users participate in R&D, they will get some compensation."

　　 "Have money for it?" Zhang Xuetong instantly simplified Huang Mao's words.

　　 Huang Mao nodded and said, "If improvement is important, people will discuss with us about purchasing technology or technology licensing. This kind of trouble, such as ours, will be a booklet for improvement."

　　 "Booklet?"

"The accessory booklet is just like the one we got." Huang Mao said as he took the manual in front of the machine, and pulled out a black-and-white printed booklet from it, and said, "Look, it's all accessories. The so-called matching, if you want to buy it, just give it to you, and they will make it for you. The price is not cheap, and it costs hundreds of thousands of dollars. Our improvements, I guess, will also be included in the accessory booklet."

　　 Zhang Xuetong nodded in a seemingly understanding, and then said: "But we still have some technologies that have not been implemented. Can we just give an idea for improvement?"

"Our thinking is complete, so we can." Huang Mao assuredly said: "When I was at Columbia University, several professors liked to do this kind of thing. If you make a slight modification, the technology company will give a lot of money. I bought a new instrument and used it for half a year. If I change it smoothly, I can save more than one and a half dollars, and I may still make a profit."

　　 "Then the technology company is losing money?"

Yang Rui couldn't help laughing: "Columbia University is an Ivy League university, a professor at Columbia University, and ordinary technology companies can't ask for it at all. People can see his instrument~www.NovelMTL.com~ to help him improve, if he is Even if they refuse to give money, their reputation in the industry will rot. Besides, they don't make money from the first batch of equipment. They can really sell a lot and make money back. It should be the second or even the third type of improved equipment. "

　　 "That's it, no wonder you are in a hurry to improve the DNA synthesizer." Zhang Xuetong completely wanted to go wrong.

　　 Yang Rui didn’t matter, and smiled: “If you can get back a little copy, Zhang Xuetong’s signature will be given to Zhang Xuetong as the second author of this paper. You also continue to work hard to stabilize the synthesis of oligonucleotides.”

　　 The clever woman can't afford to cook without rice, and without a stable supply of oligonucleotides, it is impossible to do it.

　　 This is also the performance of China's lagging behind the world in the 1980s. Today, China is similar to the Middle East countries in the 21st century. The science and technology industry is heavily biased. Oligonucleotides cannot be bought. It is also unrealistic to ship from the United States. Not to mention the large amount of demand, continuous transportation itself can easily cause unpredictable changes in raw materials.

　　 Yang Rui now misses the convenience of graduate school. At that time, as long as he had money and a phone call, countless biological companies rushed to send all kinds of materials. One of them might be opened by our school teacher...

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◇【To be continued. "". If you like this work, you are welcome to subscribe to Chuangshi for rewards. Your support is the author's greatest motivation. 】Bring your friends (@影承@白云如沟@字书文@玉树琼花满目春)